Code Anatomy - Writing high performance Python code

Writing short and efficient Python code is not always easy or straightforward. However, it's often that we see a piece of code and we don't realize the thought process behind the way it was written. We will be taking a look at the difference snippet, which returns the difference between two iterables, in order to understand its structure.
Based on the description of the snippet's functionality, we can naively write it like this:
This implementation may work well enough, but doesn't account for duplicates in b. This makes the code take more time than necessary in cases with many duplicates in the second list. To solve this issue, we can make use of the set() method, which will only keep the unique values in the list:
This version, while it seems like an improvement, may actually be slower than the previous one. If you look closely, you will see that set() is called for every item in a causing the result of set(b) to be evaluated every time. Here's an example where we wrap set() with another method to better showcase the problem:
The solution to this issue is to call set() once before the list comprehension and store the result to speed up the process:

def difference(a, b):
  return [item for item in a if item not in b]

This implementation may work well enough, but doesn't account for duplicates in b. This makes the code take more time than necessary in cases with many duplicates in the second list. To solve this issue, we can make use of the set() method, which will only keep the unique values in the list:
This version, while it seems like an improvement, may actually be slower than the previous one. If you look closely, you will see that set() is called for every item in a causing the result of set(b) to be evaluated every time. Here's an example where we wrap set() with another method to better showcase the problem:
The solution to this issue is to call set() once before the list comprehension and store the result to speed up the process:
Another option worth mentioning in terms of performance is the use of a list comprehension versus filter() and list(). Implementing the same code using the latter option would result in something like this:
Using timeit to analyze the performance of the last two code examples, it's pretty clear that using list comprehension can be up to ten times faster than the alternative. This is due to it being a native language feature that works very similar to a simple for loop without the overhead of the extra function calls. This explains why we prefer it, apart from readability.
This pretty much applies to most mathematical list operation snippets, such as difference, symmetric_difference and intersection.

From 30-seconds-of-code: code-anatomy-performant-python