Safest way to perform mysqldump on a live system with active reads and writes?

I'm not sure if this is true but I remember reading if you run the following command in linux

mysqldump -u username -p database_name > backup_db.sql

while reads and writes are being made to a database then the dump may contain errors.

Are there particular options in the command mysqldump to make sure this is done safely on a live system? I'm okay with reads/writes being disabled for our users for a few seconds (The database <50MB)

All Data is InnoDB

This is what will give you an exact point-in-time snapshot of the data:

mysqldump -uuser -ppass --single-transaction --routines --triggers --all-databases > backup_db.sql

--single-transaction produces a checkpoint that allows the dump to capture all data prior to the checkpoint while receiving incoming changes. Those incoming changes do not become part of the dump. That ensures the same point-in-time for all tables.

--routines dumps all stored procedures and stored functions

--triggers dumps all triggers for each table that has them
All Data is MyISAM or Mix of InnoDB/MyISAM

You will have to impose a global read lock, perform the mysqldump, and release the global lock

mysql -uuser -ppass -Ae"FLUSH TABLES WITH READ LOCK; SELECT SLEEP(86400)" &
sleep 5
mysql -uuser -ppass -ANe"SHOW PROCESSLIST" | grep "SELECT SLEEP(86400)" > /tmp/proclist.txt
SLEEP_ID=`cat /tmp/proclist.txt | awk '{print $1}'`
echo "KILL ${SLEEP_ID};" > /tmp/kill_sleep.sql
mysqldump -uuser -ppass --single-transaction --routines --triggers --all-databases > backup_db.sql
mysql -uuser -ppass -A < /tmp/kill_sleep.sql

Give it a Try !!!
UPDATE 2012-06-22 08:12 EDT

Since you have <50MB of total data I have another option. Instead of launching a SLEEP command into the background to hold the global read lock for 86400 sec (that 24 hr) just to get the process ID and kill outside, let's try setting a 5 second timeout in mysql rather than in the OS:

SLEEP_TIMEOUT=5
SQLSTMT="FLUSH TABLES WITH READ LOCK; SELECT SLEEP(${SLEEP_TIMEOUT})"
mysql -uuser -ppass -Ae"${SQLSTMT}" &
mysqldump -uuser -ppass --single-transaction --routines --triggers --all-databases > backup_db.sql

This is a cleaner and simpler approach for very small databases.

StackExchange Database Administrators Q#19532, answer score: 115